CRBS - Centre de recherche en biomédecine de Strasbourg - Université de Strasbourg https://crbs.unistra.fr fr CRBS - Centre de recherche en biomédecine de Strasbourg - Université de Strasbourg Mon, 24 Jun 2024 09:26:28 +0200 Mon, 24 Jun 2024 09:26:28 +0200 TYPO3 EXT:news news-16677 Thu, 11 Jul 2024 08:45:00 +0200 CRBS days 2024 /actualites/actualite/crbs-days-2024 La 3e édition des CRBS days organisé par le Comité d'animation scientifique du CRBS et en collaboration avec l'Association Doctorant et Postdoctorant du CRBS auront lieu les 11 et 12 juillet 2024.

   Dates & lieu : 11 et 12 juillet 2024,  CRBS

Ces deux journées dédiées aux résidents du CRBS auront lieu les 11 et 12 juillet 202.

Au programme, des présentations orales, des posters et un moment de convivialité pour clôturer ces journées.

 

Informations et inscription > espace collaboratif du CRBS

Organisateurs :

Comité d'animation scientifique du CRBS
crbs-animation-scientifique@unistra.fr

Association Doc et PostDoc du CRBS
crbs-2po[at]unistra.fr

]]>
Agenda du CRBS
news-16675 Thu, 20 Jun 2024 11:00:00 +0200 [CRBS Seminar] Morphology controlled nanomaterials to navigate mucosal barriers /actualites/actualite/crbs-seminar-morphology-controlled-nanomaterials-to-navigate-mucosal-barriers We are pleased to announce the seminar by Dr Kawthar Bouchemal, Institut de Recherche de Chimie Paris, CNRS UMR 8247 École Nationale Supérieure de Chimie Paris, Chimie Paris Tech, Université PSL on Thursday June 10th at 11am, on the topic “Morphology controlled nanomaterials to navigate mucosal barriers".

   Date & lieu : 20 juin 2024, 11h00, auditorium du CRBS

Morphology controlled nanomaterials to navigate mucosal barriers

by Dr Kawthar Bouchemal,
Institut de Recherche de Chimie Paris, CNRS UMR 8247,
École Nationale Supérieure de Chimie Paris, Chimie Paris Tech, Université PSL

 

Abstract: Administering drugs to mucosal sites in the body can offer several advantages. However, the design of drug carriers that can prevent dilution with physiological fluids and clearance by mucus remains a significant challenge for the scientific community. In this context, nanomaterials (NMs) coated with mucoadhesive polymers have demonstrated their potential in addressing these issues, owing to their small size and adhesive properties. Nevertheless, while there has been extensive research on the size and surface properties of NMs, there is a noticeable lack of investigations into how the morphology of NMs influences their interactions with mucosal barriers.

Our envisioned strategy involves considering the morphology of NMs as a crucial parameter for preventing mucus dilution by biological fluids, facilitating their accumulation in high concentrations near the mucosal epithelium, and promoting their internalization by epithelial cells. To understand whether NM morphology impacts their transport within mucus and their mucoadhesive properties, robust technological tools are required to create NMs with controlled characteristics.

In this regard, our research group has developed complementary processes for designing NMs with controlled morphology, allowing us to regulate aspect ratio, size, and surface modifications simultaneously. We generated nonspherical particles, referred to as "nanoplatelets," through the supramolecular and hierarchical self-assembly of α-cyclodextrin and hydrophobically modified polysaccharides with palmitic acid in water. Atomic force microscopy characterization revealed that these nanoplatelets possess flat surfaces, sharp edges, and a high aspect ratio (approximately 20).

Our findings indicate that nanoplatelets exhibit enhanced mobility in biological fluids and increased cellular internalization compared to spherical particles. Furthermore, they demonstrate superior bioadhesive properties, and through real-time in vivo imaging using a rat model, we observed that nanoplatelets exhibit longer residence times in the intestine and bladder than spherical particles. Finally, we observed that nanoplatelets possess intrinsic anti-inflammatory and anti-infective activity, whereas spherical particles remained inactive.

 

Organisateur :

Dr Benoît Frisch, Inserm Unit 1121, Unistra, EMR 7003 CNRS, Faculté de Pharmacie

]]>
Agenda du CRBS
news-16632 Tue, 11 Jun 2024 13:30:00 +0200 [CRBS Seminar series] Deconstructing human sensorimotor circuits development and diseases with in vitro models of embryogenesis /actualites/actualite/crbs-seminar-series-deconstructing-human-sensorimotor-circuits-development-and-diseases-with-in-vitro-models-of-embryogenesis Le comité d'animation scientifique du CRBS organise mensuellement un séminaire. Le mardi 11 juin, nous avons le plaisir d'accueillir Dr Stéphane Nédelec, Group leader - Cellules souches et neurodéveloppement, UMR 839, Institut du fer à moulin, Inserm / Sorbonne Université.

   Date & lieu : 11 juin 2024, 13h30,  auditorium du CRBS

Deconstructing human sensorimotor circuits development and diseases with in vitro models of embryogenesis

Dr Stéphane Nédelec, Group leader - Cellules souches et neurodéveloppement,
UMR 839, Institut du fer à moulin, Inserm / Sorbonne Université.

 

Organisateur :

Le comité d'animation scientifique du CRBS

]]>
Agenda du CRBS
news-16518 Fri, 17 May 2024 14:00:00 +0200 Soutenance HDR de Nans FLORENS, Inserm unité 1109/Unistra /actualites/actualite/soutenance-hdr-de-nans-florens-inserm-unite-1109-unistra

   Date & lieu : 17 mai 2024, 14h00, auditorium du CRBS

Soutenance d'HDR de Nans FLORENS, Inserm unité 1109, Unistra, Strasbourg

"Cross Talk Cardio-Rénal en situation pathologique”

 

Garante :

Madame la Professeure Sophie CAILLARD-OHLMANN                                                         

 

Composition du jury :

Pr Anne LEJAY

Pr Bénédicte SAUTENET

Pr Philippe OBERT

Pr Christophe MARIAT

Pr Patrice ROSSIGNOL

 

]]>
Agenda du CRBS
news-16517 Fri, 17 May 2024 11:00:00 +0200 [CRBS Seminar] Metabolic control of neocortex development /actualites/actualite/crbs-seminar-metabolic-control-of-neocortex-development We are pleased to announce the seminar by Dr Alice Davy, Centre de Biologie Intégrative de Toulouse, UMR 5077, Université de Toulouse on Friday May 17th at 11am, on the topic “PMetabolic control of neocortex development".

   Date & lieu : 14 mai 2024, 10h00, auditorium du CRBS

Metabolic control of neocortex development

by Dr Alice Davy

 

Organisateur :

Dr Caroline ROUAUX, Team leader SLA-DFT, Inserm unit 1329/Unistra

]]>
Agenda du CRBS
news-16512 Tue, 14 May 2024 13:30:00 +0200 [CRBS Seminar series] Exploring the pathophysiological substrates of restless legs syndrome: clinical approach using lesional models derived from pathology /actualites/actualite/crbs-seminar-series-exploring-the-pathophysiological-substrates-of-restless-legs-syndrome-clinical-approach-using-lesional-models-derived-from-pathology Le comité d'animation scientifique du CRBS organise mensuellement un séminaire. Le mardi 14 mai, nous accueillons Dr Elisabeth Ruppert, Maître de conférences et neurologue spécialisée dans la médecine du sommeil, CHRU Strasbourg.

   Date & lieu : 14 mai 2024, 13h30, auditorium du CRBS

Exploring the pathophysiological substrates of restless legs syndrome: clinical approach using lesional models derived from pathology

by Dr Elisabeth Ruppert

 

Organisateur :

Le comité d'animation scientifique du CRBS

]]>
Agenda du CRBS
news-16516 Tue, 14 May 2024 10:00:00 +0200 [CRBS Seminar] Prediction of low-risk progressors in clear cell renal cell carcinoma patients based on single-cell RNA-seq /actualites/actualite/crbs-seminar-prediction-of-low-risk-progressors-in-clear-cell-renal-cell-carcinoma-patients-based-on-single-cell-rna-seq We are pleased to announce the seminar by Aurélie Lardenois, Irset - Inserm UMR 1085 on Tuesday May 14th at 10am, on the topic “Prediction of low-risk progressors in clear cell renal cell carcinoma patients based on single-cell RNA-seq".

   Date & lieu : 14 mai 2024, 10h00, auditorium du CRBS

Prediction of low-risk progressors in clear cell renal cell carcinoma patients  based on single-cell RNA-seq

by Dr Aurélie Lardenois

 

Organisateur :

Julie Thompson, Team CSTB, UMR 7357 - I Cube

]]>
Agenda du CRBS
news-16299 Thu, 28 Mar 2024 14:00:00 +0100 Soutenance de thèse de Marguerite Jamet, U 1329 /actualites/actualite/soutenance-de-these-de-marguerite-jamet-u-1329

   Date & lieu : 28 mars 2024, 14h, auditorium du CRBS

Sujet : Contribution des oligodendrocytes à la Sclérose Latérale Amyotrophique et la Démence Frontotemporale liées à FUS

 

Directeurs de thèse :

Dr Luc Dupuis, Directeur de recherche, Inserm U 1329, Unistra

Dr José-Luis Gonzalez de Aguilar, Enseignant chercher, Inserm U 1329, Unistra

 

Membres du jury :

Sandrine Da Cruz, Professeure

Christian Lobsiger, Directeur de recherche,

Chantal Mathis, Directrice de recherche,

Brahim Nait Oumesmar, Directeur de recherche

]]>
Agenda du CRBS
news-16199 Tue, 12 Mar 2024 13:30:00 +0100 [CRBS Seminar series] Networks of habenula-projecting cortical neurons regulate cocaine seeking /actualites/actualite/crbs-seminar-series-networks-of-habenula-projecting-cortical-neurons-regulate-cocaine-seeking Le comité d'animation scientifique du CRBS organise mensuellement un séminaire. Le mardi 12 mars, nous accueillons Victor Mathis, post-doctorant, Team 5: Neuroanatomy, Pain and Psychopathology Institute of Cellular and Integrative Neuroscience - INCI, CNRS.

   Date & lieu : 12 mars 2024, 13h30, auditorium du CRBS

  • Sujet : Networks of habenula-projecting cortical neurons regulate cocaine seeking

 

 

Organisateur :

Le comité d'animation scientifique du CRBS

]]>
Agenda du CRBS
news-15891 Wed, 31 Jan 2024 14:00:00 +0100 Soutenance HDR de Vincent GIES, U 1109 /actualites/actualite/soutenance-hdr-de-vincent-gies-u-1109

   Date & lieu : 31 janvier 2024, 14h00, auditorium du CRBS

Soutenance d'HDR de Vincent GIES, Inserm unité 1109, Unistra, CRBS, Strasbourg

"Tolérance lymphocytaire B et maladies auto-immunes”

 

Garante :

Madame la Professeure KORGANOW Anne-Sophie                                                              

INSERM UMR-S1109 ▪ Cheffe de service ; Service de Médecine Interne et d’Immunologie Clinique ▪ CHU de Strasbourg ▪ Strasbourg ▪ France

 

Composition du jury :

Madame la Docteure ESPELI Marion                                                                                                      

INSERM U1160 ▪ Université Paris-Descartes ▪ Institut de Recherche Saint-Louis ▪ Paris ▪ France

Monsieur le Professeur BELOT Alexandre

INSERM U1111 ; Service de Néphrologie-Rhumatologie-Dermatologie Pédiatrique ▪ Hôpital Femme Mère Enfant ▪ Hospices Civils de Lyon ▪ Lyon ▪ France

Monsieur le Professeur GOTTENBERG Jacques-Eric                                   

CNRS UPR3572 ▪ Chef de service ; Service de Rhumatologie ▪ CHU de Strasbourg ▪ Strasbourg ▪ France

Madame la Professeure RIZZI Marta

Service de Rhumatologie et d’Immunologie Clinique ▪ Centre pour les Immunodéficiences Chroniques ▪ Faculté de médecine ▪ Freiburg ▪ Allemagne

 

]]>
Agenda du CRBS
news-15875 Wed, 24 Jan 2024 09:00:00 +0100 Soutenance de thèse d'Amani ABOU RIDA, UMR 7357 /actualites/actualite/soutenance-de-these-damani-abou-rida-umr-7357

   Date & lieu : 24 janvier 2024, 9h, auditorium du CRBS

Sujet : Enhancing the Detection and Explainability in Cybersecurity : A Shift from Machine Learning to Graph Learning

 

Directeurs de thèse :

Pierre Parrend, Aline Deruyver

 

Membres du jury :

Reporters:  Prof. Hervé Debar, Prof. Valeria Loscri

Examinators: Prof. Marc-Oliver Pahl, Prof. Cristel Pelsser, Dr. Anne Jeannin-Girardin, Dr. Martin Husak

 

]]>
Agenda du CRBS
news-15458 Mon, 04 Dec 2023 14:00:00 +0100 Soutenance de thèse de Valentin GENSBITTEL, U 1109 /actualites/actualite/soutenance-de-these-de-valentin-gensbittel-u-1109

   Date & lieu : 4 décembre 2023, 12h, auditorium du CRBS

Sujet : Importance des propriétés mécaniques des cellules tumorales circulantes au cours du développement métastatique 

 

Directeur de thèse :

Dr. Jacky GOETZ, DR, Inserm unité 1109, Unistra

 

Membres du jury :

  • Dr. Jean-Baptiste MANNEVILLE, DR, Université Paris Cité

  • Dr. Julie PANNEQUIN, DR, Institut de Génomique Fonctionnelle

  • Dr. Sandrine ETIENNE-MANNEVILLE, DR, Institut Pasteur

  • Dr. Anne-Cécile REYMANN, CR, IGBMC

 

]]>
Agenda du CRBS
news-15454 Fri, 01 Dec 2023 16:00:00 +0100 Soutenance de thèse de Yannick DIEUDONNE, U 1109 /actualites/actualite/soutenance-de-these-de-yannick-dieudonne-u-1109

   Date & lieu : 1er décembre 2023, 16h, auditorium du CRBS

Sujet : Les cellules B dans le syndrome des antiphospholipides primaire : approche à partir d’une cohorte de patients avec triple positivité  

 

Directrice de thèse :

Professeur Anne-Sophie KORGANOW

 

Membres du jury :

  • Dr Hélène DUMORTIER

  • Docteur Vincent GIES

  • Professeur Matthieu MAHÉVAS

  • Professeur Eric MEFFRE

  • Professeur Marta RIZZI

 

]]>
Agenda du CRBS
news-15292 Tue, 21 Nov 2023 14:00:00 +0100 [CRBS Seminar series] : A new link between Endoplasmic Reticulum-Endosome contacts and cancer /actualites/actualite/crbs-seminar-series-a-new-link-between-endoplasmic-reticulum-endosome-contacts-and-cancer Le comité d'animation scientifique du CRBS organise mensuellement un séminaire. Au mois de novembre, nous accueillons Catherine-Laure TOMASETTO, directrice de recherche, Group leader (Biologie moléculaire et cellulaire des cancers du sein), IGBMC, Inserm, Université de Strasbourg.

   Date & lieu : 21 novembre 2023, 14h, auditorium du CRBS

  • Sujet : A new link between Endoplasmic Reticulum-Endosome contacts and cancer

 

 

Organisateur :

Le comité d'animation scientifique du CRBS

]]>
Agenda du CRBS
news-15288 Thu, 16 Nov 2023 13:45:00 +0100 Soutenance de thèse de Margaux HEUSCHKEL, U 1110 /actualites/actualite/soutenance-de-these-de-margaux-heuschkel-u-1110

   Date & lieu : 16 novembre 2023, 13h45, auditorium du CRBS

Sujet : Caractérisation de la Janus kinase JAK1 comme facteur d’hôte du virus de l’hépatite D et cible antivirale  

 

Directeur de thèse :

Dr. Eloi VERRIER, HDR, CR Inserm, Inserm U1110, Strasbourg

 

Membres du jury :

  • Dr. Caroline GOUJON, HDR, CR Inserm, IRIM, Montpellier
  • Dr. Camille SUREAU, DR CNRS, Université de Tours
  • Pr. Sylvie FOURNEL, HDR, PU, Université de Strasbourg
  • Dr. David DURANTEL, HDR, DR Inserm, CIRI, Lyon

 

]]>
Agenda du CRBS
news-15368 Thu, 16 Nov 2023 11:00:00 +0100 [CRBS Seminar] Intrinsic and innate immune defense mechanisms against SARS-CoV-2 /actualites/actualite/crbs-seminar-intrinsic-and-innate-immune-defense-mechanisms-against-sars-cov-2 We are pleased to announce the seminar by Dr Caroline Goujon, Groupe Leader, Interferon and Antiviral Restriction Lab, Institut de Recherche en Infectiologie de Montpellier, IRIM UMR 9004, CNRS - Montpellier University on Thursday November 16th at 11am, on the topic “Intrinsic and innate immune defense mechanisms against SARS-CoV-2"

   Date & lieu : 16 novembre 2023, 11h, auditorium du CRBS

Sujet : Intrinsic and innate immune defense mechanisms against SARS-CoV-2

 

 

Caroline Goujon studied at the Ecole Normale Supérieure-Lyon (France), and did her PhD in Andrea Cimarelli’s team, where she studied the restriction of HIV-1 infection in myeloid cells and discovered that HIV-2 protein Vpx was able to counteract a restriction factor (later on identified by others as SAMHD1).


After gaining her PhD in 2007, she joined Prof. Michael Malim's group at King's College London (UK) in 2008 and was awarded a Marie Curie Intra-European Fellowship to initially study primary T cells responses to HIV-1 infection. She became interested in the interferon-induced restriction of HIV-1 and identified MX2 (or MxB) as one of the main players. In 2014, she was awarded the Andy Kaplan prize, which honors the accomplishments of a postdoctoral scientist in the retrovirology field. In 2015, she moved back to France and started her own lab at the CNRS/Montpellier university co-funded IRIM institute (Institut de Recherche en Infectiologie de Montpellier), thanks to the support of an INSERM tenure position and a CNRS/INSERM (ATIP-Avenir) starting grant. Using major pathogenic viruses as models, Caroline studies the innate cellular defense mechanisms against viral infections and was awarded an ERC StG in 2017 to pursue her work.


Since the COVID-19 pandemic, her team has been mainly focusing on studying the interplay of host cells and respiratory viruses, including SARS-CoV-2 and influenza A virus. She has just been awarded an ERC CoG to study this interplay in primary airway epithelia.

 

Organisateur :

Philippe BOUCHER, unité 1109 Inserm/Unistra

 

]]>
Agenda du CRBS
news-15289 Tue, 14 Nov 2023 14:00:00 +0100 [CRBS Seminar] Non vesicular cholesterol transport in the control of cholesterol homeostasis /actualites/actualite/crbs-seminar-non-vesicular-cholesterol-transport-in-the-control-of-cholesterol-homeostasis We are pleased to annouce the seminar by Dr Alessandra Ferrari, Research scientist in the Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA Laboratory of Prof. Peter Tontonoz on Tuesday November 14th at 2pm, on the topic “Non vesicular cholesterol transport in the control of cholesterol homeostasis"

   Date & lieu : 14 novembre 2023, 14h, auditorium du CRBS

Sujet : Non vesicular cholesterol transport in the control of cholesterol homeostasis

 

Abstract:

Intestinal cholesterol absorption is an important contributor to systemic cholesterol homeostasis.  Niemann-Pick C1 Like 1 (NPC1L1) assists in the initial step of dietary cholesterol uptake.  However, how cholesterol moves downstream of NPC1L1 is unknown.  Here we show that Aster-B and Aster-C are critical for non-vesicular cholesterol movement in enterocytes. Loss of NPC1L1 diminishes accessible plasma membrane (PM) cholesterol in enterocytes and abolishes Aster recruitment to the intestinal brush border.  Enterocytes lacking Asters accumulate cholesterol at the PM and display evidence of endoplasmic reticulum (ER) cholesterol depletion.  Aster-deficient mice have impaired cholesterol absorption and are protected against diet-induced hypercholesterolemia.  Aster pathway can be targeted with a small molecule inhibitor to manipulate dietary cholesterol uptake.  These findings identify the Aster pathway as a physiologically important and pharmacologically tractable node in dietary lipid absorption.  

 

Organisateur :

Philippe BOUCHER, unité 1109 Inserm/Unistra

 

]]>
Agenda du CRBS
news-15309 Tue, 07 Nov 2023 09:00:00 +0100 Soutenance de thèse d'Hiba KHODJI, UMR 7357 /actualites/actualite/soutenance-de-these-dhiba-khodji

   Date & lieu : 7 novembre 2023, 9h, auditorium du CRBS

Sujet : Deep learning and knowledge transfer for the detection of errors in biological sequences

 

Directeurs de thèse :

Dr. Julie Thompson et Pr. Pierre Collet

 

Membres du jury :

  • Rapporteurs : Dr. Laurent Jacob et Dr. Marie-Dominique Devignes

  • Examinateurs : Dr. Yann Guermeur et Dr. Farida Zehraoui

]]>
Agenda du CRBS
news-15285 Fri, 03 Nov 2023 14:00:00 +0100 [CRBS Seminar] Lipid metabolism alterations in FUS-linked amyotrophic lateral sclerosis (ALS) /actualites/actualite/crbs-seminar-lipid-metabolism-alterations-in-fus-linked-amyotrophic-lateral-sclerosis-als We are pleased to annouce the seminar by Dr Thibaut Burg, FWO Postdoctoral researcher, Ludo Van Den Bosch’s Lab on Friday November 3rd at 2pm, on the topic “Lipid metabolism alterations in FUS-linked amyotrophic lateral sclerosis (ALS)".

   Date & lieu : 3 novembre 2023, 14h, auditorium du CRBS

Sujet : Lipid metabolism alterations in FUS-linked amyotrophic lateral sclerosis (ALS)

 

Abstract:

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease of the adult motor system, for which effective treatments remain elusive. Mutations leading to the mislocalization of FUS, an essential RNA-binding protein, have been linked to the most severe form of ALS. Despite intense research efforts, the cascade of pathological events triggering the progressive degeneration of motor neurons remains incompletely understood. Our prior investigations revealed significant lipid metabolism alterations in the spinal cord of a FUS mouse model, as well as in motor neurons derived from ALS patients induced pluripotent stem cells (iPSCs). Recent evidence suggests that dysfunctional glial cells, including oligodendrocytes, contribute to neurodegeneration in FUS-linked ALS through non-cell autonomous mechanisms. In our latest research, we investigated the impact of FUS mutations in oligodendrocyte progenitor cells (OPCs) derived from human iPSCs. Confirming the cytoplasmic mislocalization of FUS in OPCs, we uncovered significant alterations in lipid metabolism, accompanied by transcriptomic alterations related to myelin formation. Additionally, we observed mitochondria-associated ER membrane abnormalities, ER stress, and mitochondrial dysfunctions. These recent findings emphasize the pathological role of FUS in oligodendrocytes, shedding light on the intricate cellular mechanisms contributing to FUS-linked ALS pathology.

 

Organisateur :

Caroline ROUAUX, unité 1118 Inserm/Unistra

 

]]>
Agenda du CRBS
news-14871 Thu, 26 Oct 2023 14:00:00 +0200 Soutenance de thèse d'Erin JOHNS, UR 7296-UMR 7357 /actualites/actualite/soutenance-de-these-derin-johns-ur-7296-umr-7357

   Date & lieu : 26 octobre 2023, 14h, auditorium du CRBS

Sujet : L'intelligence artificielle au service de la pharmacie clinique à l'hôpital : construction d'algorithmes prédictifs d'aide à l'expertise pharmaceutiques des prescriptions médicamenteuses.

 

Directeurs de thèse :

Dr Bruno MICHEL, UR 7296

Dr Erik-André SAULEAU, UMR7357

 

 

]]>
Agenda du CRBS
news-14869 Thu, 26 Oct 2023 09:00:00 +0200 Soutenance de thèse d'Alice RESSAULT, UR 7296 /actualites/actualite/soutenance-de-these-dalice-ressault-ur-7296

   Date & lieu : 26 octobre 2023, 9h, auditorium du CRBS

Sujet : Préparation nasale d'halopéridol : formulation, étude de stabilité physicochimique et essais in vitro 

 

Directrice de thèse :

Dr Anne DORY, CHU de STRASBOURG, UR 7296

 

Composition du jury :

  • Dr Anne DORY, CHU de STRASBOURG, UR 7296

  • Pr Laurent Monassier, UR 7296

  • Pr Olivier Joubert, Faculté de Nancy

  • Pr Geneviève Ubeaud-Sequier, UMR 1260

 

 

]]>
Agenda du CRBS
news-14819 Fri, 20 Oct 2023 14:00:00 +0200 Soutenance de thèse de Corentin Meyer, UMR 7357 /actualites/actualite/soutenance-de-these-de-corentin-meyer-umr-7357

   Date & lieu : 20 octobre 2023, 14h, auditorium du CRBS

Sujet : Méthodes d’exploitation de données multimodales de patients par intelligence artificielle : application aux myopathies congénitales

 

Directeurs :

Dr. POCH Olivier, directeur de recherche CNRS (ICube)

Pr. COLLET Pierre, Professeur Université de Strasbourg

Composition du jury :

  • Rapporteur #1 : Malika Smail-Tabbone, Maître de conférences Université de Loraine

  • Rapporteur #2 : Antonio Rauell, Maître de conférences Université de Paris

  • Examinateur #1 : Gisèle Bonne, Directrice de Rechercher INSERM Paris

  • Examinateur #2 : Cédric Wemmert, Professeur Université de Strasbourg

]]>
Agenda du CRBS
news-14825 Thu, 19 Oct 2023 14:00:00 +0200 Soutenance de thèse de Damien FREYTAG, U1109 /actualites/actualite/soutenance-de-these-de-damien-freytag-u1109

   Date & lieu : 19 octobre 2023, 14h, auditorium du CRBS

Sujet : Étude des dysfonctions lymphocytaires T dans un modèle murin gain de fonction de STING

 

Directrice de thèse : Pr Pauline SOULAS-SPRAUEL (PU-PH, Inserm UMR 1109)

Composition du jury :

  • Dr Thierry WALZER (DR, Inserm U1111)

  • Dr Marie-Louise FRÉMOND (MCU-PH, Inserm U1163

  • Dr Céline CHARVET (CR, CNRS UMR 7104 – Inserm U1258)

  • Dr Nicolas RITEAU (CR, CNRS UMR 7355)

 

 

]]>
Agenda du CRBS
news-14771 Fri, 06 Oct 2023 11:00:00 +0200 Octobre Rose au CRBS : séminaire et session posters /actualites/actualite/octobre-rose-au-crbs-seminaire-et-session-posters Le comité d'animation scientifique du CRBS propose une programmation spéciale 'Octobre Rose' durant ce mois de prévention et de sensibilisation au cancer du sein.

Date & lieu : 6 octobre 2023, 11h, auditorium du CRBS

  • Topic : Intravascular Cues Shape Tumor Metastasis by Jacky Goetz, Inserm unit 1109, Unistra

 

Session posters dans le bâtiment

 

]]>
Agenda du CRBS
news-14752 Mon, 02 Oct 2023 14:00:00 +0200 Soutenance de thèse d'Adella Karam, U 1112 /actualites/actualite/soutenance-de-these-dadella-karam-u-1112

   Date & lieu : 2 octobre 2023, 14h, auditorium du CRBS

Sujet : Caractérisation des phénotypes ciliaires cellulaires et contribution à la validation fonctionnelle de variants pathogènes de gènes de ciliopathies

 

Directrice : Pr. Hélène Dollfus, Inserm U 1112, Unistra

Composition du jury :

  • Dr. Jean Muller, Co-directeur de thèse
  • Pr. Bénédicte Durand, Rapporteur Externe
  • Dr. Isabelle PERRAULT, Rapporteur externe
  • Dr. Jocelyn Laporte, Examinateur interne
]]>
Agenda du CRBS
news-14750 Fri, 29 Sep 2023 14:00:00 +0200 Soutenance de thèse de Benjamin ANIZON, U1119 /actualites/actualite/soutenance-de-these-de-benjamin-anizon-u1119

   Date & lieu : 29 septembre 2023, 14h, auditorium du CRBS

Sujet : Identification de nouveaux neuroprotecteurs dans la lutte contre la sclérose en plaques (SEP) : évaluation préclinique du potentiel neuroprotecteur du neurostéroïde 3α-O-allyl-allopregnanolone (BR351) dans un modèle animal de la SEP

 

Directrice : Dr. Christine PATTE-MENSAH

Co-directeur : Pr. Ayikoé, Guy MENSAH-NYAGAN

]]>
Agenda du CRBS
news-14749 Fri, 29 Sep 2023 11:00:00 +0200 CRBS Conference : A predictive-processing account of psychosis /actualites/actualite/crbs-conference-a-predictive-processing-account-of-psychosis We are pleased to annouce the conference by Philip Sterzer, MD, on the topic “A predictive-processing account of psychosis”.

   Date & lieu : 29 septembre 2023, 11h, auditorium du CRBS

  • Sujet : A predictive-processing account of psychosis

Abstract : 

There has been an increasing interest in the neurocomputational mechanisms underlying psychotic disorders in recent years. One promising approach is based on the theoretical framework of predictive processing, which proposes that inferences regarding the state of the world are made by combining prior beliefs with sensory signals. Delusions and hallucinations are the core symptoms of psychosis and often co-occur. Yet, different predictive-processing alterations have been proposed for these two symptom dimensions, according to which the relative weighting of prior beliefs in perceptual inference is decreased or increased, respectively. I will present recent behavioural, neuroimaging, and computational work that investigated perceptual inference to elucidate the changes in predictive processing that may give rise to psychotic experiences. Based on the empirical findings presented, I will provide a more nuanced predictive-processing account that suggests a common mechanism for delusions and hallucinations at low levels of the predictive-processing hierarchy, but still has the potential to reconcile apparently contradictory findings in the literature. This account may help to understand the heterogeneity of psychotic phenomenology and explain changes in symptomatology over time.

Biography :

Philipp Sterzer is a psychiatrist, neurologist and neuroscientist who trained in Frankfurt am Main, London and Berlin and held a professorship for psychiatry and computational neuroscience at Charité Berlin from 2011 to 2022. Recently, he was appointed Professor of Translational Psychiatry at University of Basel, Switzerland. His work focuses on the investigation of predictive neural processes in perception and their alterations in psychotic disorders using functional neuroimaging and computational modeling among other methods. Along with numerous articles in scientific journals and textbooks, he recently published “Die Illusion der Vernunft”, a popular science book on delusions and other irrational beliefs.

Organisateur :

Anne Giersch, Inserm U 1114, Unistra, CRBS, Strasbourg

 

 

]]>
Agenda du CRBS
news-14668 Tue, 19 Sep 2023 14:00:00 +0200 Soutenance de thèse de Rana SMAIDA, U1260 /actualites/actualite/soutenance-de-these-drana-smaida-u1260

   Date & lieu : 19 septembre 2023, 14h, auditorium du CRBS à huis-clos

Sujet : Développement d'un médicament de thérapie innovante combinant des cellules souches et un dispositif médical implantable pour la médecine régénérative

 

Directrices de thèse:

  • Dr. Nadia Benkirane-Jessel, Directrice de recherche, DU, Inserm U1260, Unistra
  • Dr. Sabine Bopp-Kuchler, Chargée de recherche, Inserm U1260, Unistra

 

Composition du jury:

Pr. Philippe Georgel, PU, Université de Strasbourg

Pr. Natalia de Isla, PU, Université de Lorraine

Pr. Didier Mainard, PU-PH, Université de Lorraine

Dr. Louis-Romée Le Nail, MCU-PH, CHRU de Tours

 

 

]]>
Agenda du CRBS
news-14655 Fri, 15 Sep 2023 14:00:00 +0200 Soutenance de thèse d'Eloïse LEBAUDY, U1121 /actualites/actualite/soutenance-de-these-deloise-lebaudy-u1121

   Date & lieu : 15 septembre 2023, 14h, auditorium du CRBS

Sujet : Hydrogels à base de poly(éthylène glycol) et de peptides aux propriétés anti-infectieuses et pro-régénératives

 

Directeur de thèse:

Philippe LAVALLE, Directeur de Recherche, Inserm unité 1121, Université de Strasbourg

 

Composition du jury:

Pr. Ariane BOUDIER (Professeure, Université de Lorraine)

Dr. Vincent HUMBLOT (Directeur de Recherche, CNRS)

Dr. Cécile FORMOSA-DAGUE (Chargée de Recherche, CNRS)

Pr. Loïc Jierry (Professeur, Université de Strasbourg)

 

 

]]>
Agenda du CRBS
news-14682 Fri, 15 Sep 2023 11:00:00 +0200 CRBS Conference : Heart repair with cardiac spheroids and biomaterials /actualites/actualite/crbs-conference-heart-repair-with-cardiac-spheroids-and-biomaterials We are pleased to announce the conference by Pr Carmine Gentile, School of Biomedical Engineering/Faculty of Engineering and IT, University of Technology Sydney on the topic “Heart repair with cardiac spheroids and biomaterials”.

   Date & lieu : 15 septembre 2023, 11h, auditorium du CRBS

  • Sujet : Heart repair with cardiac spheroids and biomaterials

Biosketch:

Dr Carmine Gentile, PharmD/PhD, FAHA, leads the Cardiovascular Regeneration Group working on 3D bioprinting and stem cell technologies at the University of Technology Sydney (UTS). He is also a Senior Lecturer (Faculty) within the School of Biomedical Engineering (Faculty of Engineering and IT) at the UTS. He received his BSc/MSc (Pharmaceutical Chemistry and Technologies) and PharmD at the University of Pisa, Italy and his PhD in Biomedical Sciences (Cardiovascular) at the Medical University of South Carolina, Charleston, SC, USA, funded by a prestigious American Heart Association Fellowship. Since 2013 Dr Gentile has worked in Australia at the Heart Research Institute, the University of Sydney and now at UTS, supported by several awards and grants, working within a multidisciplinary team with scientists, industry partners and clinicians to quickly translate his findings from bench to bedside. Dr Gentile is internationally recognized for his studies in 3D bioprinting and stem cell technologies and his more recent studies focus on novel molecular and cellular approaches to treat cardiovascular disease, including myocardial infarction and heart failure. These studies are based on the use of “mini-hearts” he developed as “bioinks” for human heart tissues. In 2016, he was invited as Visiting Research Fellow at Harvard Medical School, where he worked towards novel in vitro models using mini-hearts to study human heart pathophysiology.

 

Organisateur:

Canan Nebigil, Inserm U1260, Unistra

]]>
Agenda du CRBS